More on Amox!
Amoxicillin is easily one of the world’s most popular and recognizable anti-biotics. It still is the first line of defense against the most common infection known to man. Unfortunately, through the years, it has grown to have a reputation as a cure-all. As a result, the drug has been misused tremendously. The misuse has led to the unfortunate rise in drug-resistant strains of pathogens.
Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.
The first paragraph just about sums up every answer to questions raised in the previous post.
Putting Amoxicillin on your wound will not help at all!
   Like the article puts it, the drug is absorbed following oral administration. It doesn’t work like an antiseptic when it direct contact with an open wound. Is it harmful to do it? Well, there have been no studies regarding this peculiar practice, but it is a waste.
Self-medication with any unprescribed antibiotic is still a NO-NO!
Most infections and diseases that an healthy human being gets are usually a result of organisms that are self-limiting (i.e. will resolve even without treatment) and using antibiotics in the event of the condition is not only wasteful - it’s also potentially hazardous in the long run.
Let’s all make rational drug use our advocacy!
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So we basically can’t use it for just a simple headache or a mild fever. Then.. what is the most advisable medicine that we can take if we have such ailments?
Haa, even though generally i dont have interest in Medicine, your medical related blog entries are informative!
Thanks!
So putting that in an open wound does not help in any way. That’s informative, thanks! I just remembered that my mom believes in that kind of things. She usually have amoxicillin put in an open wound in hope that it would heal immediately.
hmm interesting…sprinkling amoxicillin on the wound worked for me…whenever i have wounds that don’t seem to heal, i sprinkle amox, and the wounds heal in a day or two.
i read in a forum once about a medical practitioner saying that when she was assigned in some poor country and supplies were limited, they sprinkled amox on the patients’ wounds instead of having the patients take amox orally…it reduced cost for the patient and the limited amox supply lasted a long way and helped more people…
tho of course i agree that we shouldn’t take amox as casually as we do OTC medicines
unang tingin pa lang sa molecular arrangement / whatever that is, i expected this to be a nerdy post. and yeah, i heard hazardous ang antibiotics in the long run kasi it also kills the disease-fighting cells or something like that. hehe.
amoxicillin is different from penicillin… Penicillin, though also an antibiotic is the drug of choice for open wounds… The only drug classifications that are used with no prescriptions needed are ibuprofen, anti-inflammatory, and analgesics like paracetamol…
To add, if you take antibiotics without doctors advise, and you take higher dose more than the usual dosage you take,you tend to be resistant to that certain drug already, hence, you need to take a higher dose of drug, that’s why it is harmful… There are a lot of antibiotics and it is also the most harmful drug classification of all, for me.
ex links? hehe
Yay to your rational drug use advocacy!
Yeah, same with Joe. I thought this was some kind of nerdy post ranting on and on about the latest scientific commotion that we wouldn’t understand. Haha.
Waaaah. I scrolled down and read your past posts, o_O BLOOOOD! *runs away, screaming*
How’s the thumb? o_O
I had this prescribed when I had a tooth infection. Damn did wonders for me. My back cleared from any pimples and my face was the best it looked since I was a kid! LOL
thanks Dr Benj for the informative post, correcting the wrong impressions most people have on some old wives’ tales.
Taking any drugs without a doctor’s prescription is definitely a no-no.
But yes, I only inhaled. :p
Inhalants are the worst kind of drug!! LOL.
wow, thanks! I’ll keep this in mind the next time my mom prescribes me amoxicillin!LoL
My tatay used to sprinkle the powder to my wounds when I was a bit younger. It’s something that he learned from my lolo. I think it’s Penicillin.
Self-medication is also not good for your pets, please consult your veterinarian. (”,)